Large Granular Lymphocyte Leukemia and Precapillary Pulmonary Hypertension
نویسندگان
چکیده
منابع مشابه
Large granular lymphocyte leukemia.
Clonal diseases of large granular lymphocytes (LGLs) represent a spectrum of clinically rare lymphoproliferative malignancies arising from either mature T-cell (CD3(+)) or natural killer (NK)-cell (CD3(-)) lineages. The clinical behavior of these disorders ranges from indolent to very aggressive. Patients with symptomatic indolent T-cell or NK-cell LGL leukemia are usually treated with immunosu...
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A 50-year-old female with low-grade chronic anemia and no other medical problems was evaluated when her hemoglobin fell to 8.2 g/dL. She had no adenopathy or hepatosplenomegaly. Her white cell count was 7.7 109/L with a lymphocyte count of 6.2 109/L, platelets 498 109/L, and reticulocyte count that was normal. Serum electrophoresis and rheumatoid factor were negative and ANA was weakly positive...
متن کاملLarge Granular Lymphocyte Leukemia as a Complication of Rheumatoid Arthritis
Large granular lymphocyte leukemia is a rare entity belonging to same spectrum of diseases than Felty’s syndrome, which might occur in patients with long-standing rheumatoid arthritis. It is clinically characterized by persistent neutropenia and recurrent bacterial infections associated with the presence in both peripheral blood and bone marrow of clonal expansion of atypic lymphocytes with a c...
متن کاملNetwork model of survival signaling in large granular lymphocyte leukemia.
T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling components that determine the survival of CTL in T-LGL leukemia, we constructed a T-LGL survival signaling network by integrating the signaling pathways involved in normal CTL activation and the known deregulations of s...
متن کاملA population-based study of large granular lymphocyte leukemia
Large granular lymphocyte (LGL) leukemia is a lymphoproliferative disorder of cytotoxic cells. T-cell LGL (T-LGL) leukemia is characterized by accumulation of cytotoxic T cells in blood and infiltration of the bone marrow, liver or spleen. Population-based studies have not been reported in LGL leukemia. We present clinical characteristics, natural history and risk factors for poor survival in p...
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ژورنال
عنوان ژورنال: Chest
سال: 2020
ISSN: 0012-3692
DOI: 10.1016/j.chest.2020.07.094